This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Use of anastrozole for breast cancer prevention (IBIS-II): long term results of a randomized controlled trial. Lancet 2020; 395: 117-122

Published: 5th March 2020

Authors: Cuzik J, Sestak I, Forbes JF, Dowsett M, Cawthorn S, Mansel RE et al.

Conclusion

After median follow-up of 131 months in this study that included 3864 women, five years of anastrozole reduced the risk of breast cancer: hazard ratio 0.51, 95 per cent confidence interval 0.39 to 0.66, P<0.0001. The reduction was greatest for the first five years, but still significant thereafter (0.64, 0.45 to 0.91, P=0.014).

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