This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Sorafenib for advanced and refractory desmoid tumors. N Engl J Med 2018; 379: 2417-2428.

Published: 22nd March 2019

Authors: Gounder MM, Mahoney MR, Van Tine BA, Ravi V, Attia S, Deshpande HA et al.

Conclusion

Eight-seven patients with symptomatic or recurrent desmoids were included. Sorafenib improved 2-year progression-free survival from 36 to 81 per cent; hazard ratio 0.13, 95 per cent confidence interval 0.05 to 0.31, P<0.001.

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