The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of oral moxifloxacin vs intravenous ertapenem plus oral levofloxacin for treatment of uncomplicated acute appendicitis. The APPAC II randomized clinical trial. JAMA 2021; 325: 353-362.

Published: 9th June 2021

Authors: Sipppola S, Haijanen J, Gronooos J, Rautio T, Nordstrom P, Rantanen T et al.

Conclusion

Some 583 patients were included. Successful treatment (defined as discharged without surgery and no recurrent appendicitis within one year) was recorded in 70.2 per cent after oral antibiotics and 73.8 per cent after intravenous antibiotics first (P=0.26 for non-inferiority).

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