This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Five-year analysis of adjuvant dabrafenib plus trametinib in Stage III Melanoma. N Engl J Med 2020; 383: 1139-1148.

Published: 17th November 2020

Authors: Dummer R, Hauschild A, Santinami M, Atkinson V, Mandala M, Kirkwood JM et al.

Conclusion

A total of 870 patients were included originally. Adjuvant treatment was given for one year. At median follow-up of 60 months, more patients were alive without distant metastases in the active treatment group: 65 versus 54 per cent, hazard rate ratio for relapse or death 0.55, 95% confidence interval 0.42 to 0.61.

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Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet 2020; 395: 1558-1568.

Authors: Zimmer S, Livingstone E, Hassel JC, Fluck M, Eigentler T, Loquai C et al.

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2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial. Lancet 2019; 394: 471-477.

Authors: Utjes D, Malmstedt J, Teras J, Drzewiecki K, Gullestad HP, Ingvar C et al.

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Phase III randomized study of 4 weeks of high-dose interferon-α-2b in stage T2bNO, T3a-bNO, T4a-bNO, and T1-4N1a-2a (microscopic) melanoma: a trial of the Eastern Cooperative Oncology Group–American College of Radiology Imaging Network Cancer Research Group (E1697). J Clin Oncol 2017; 35: 885-892.

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Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N Engl J Med 2016; 375: 1845-1855.

Authors: Eggermont AMM, Chiarion-Sileni V, Grob J-J, Dummer R, Wolchok JD, Schmidt H et al.

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Final results of the Sunbelt Melanoma Trial: a multi-institutional prospective randomized phase III study evaluating the role of adjuvant high-dose interferon alfa-2b and completion lymph node dissection for patients staged by sentinel lymph node biopsy. J Clin Oncol 2016; 34: 1079-1086.

Authors: McMasters KM, Egger ME, Edwards MJ, Ross MI, Reintgen DS, Noyes RD et al.

Five-year analysis of adjuvant dabrafenib plus trametinib in Stage III Melanoma. N Engl J Med 2020; 383: 1139-1148.

Conclusion

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Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet 2020; 395: 1558-1568.

2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial. Lancet 2019; 394: 471-477.

Adjuvant pembrolizumab versus placebo in resected stage III melanoma. N Engl J Med 2018; 378: 1789-1801.

Adjuvant nivolumab versus ipilimumab in resected stage III or IV melanoma. N Engl J Med 2017; 377: 1824-1835.

Adjuvant dabrafenib plus trametinib in stage III BRAF-mutated melanoma. N Engl J Med 2017; 377: 1813-1823.

Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med 2017; 376: 2211-2222.

Completion dissection or observation for sentinel-node metastasis in melanoma. N Engl J Med 2017; 376: 2211-2222.

Prolonged survival in stage III melanoma with ipilimumab adjuvant therapy. N Engl J Med 2016; 375: 1845-1855.

Final results of the Sunbelt Melanoma Trial: a multi-institutional prospective randomized phase III study evaluating the role of adjuvant high-dose interferon alfa-2b and completion lymph node dissection for patients staged by sentinel lymph node biopsy. J Clin Oncol 2016; 34: 1079-1086.