This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

Effect of early surgery vs endoscopy-first approach on pain in patients with chronic pancreatitis. The ESCAPE randomized clinical trial. JAMA 2020; 323: 237-247

Published: 20th March 2020

Authors: Issa Y, Kempeneers MA, Bruno MJ, Fockens P, Poley J-W, Ali UA et al.

Conclusion

Eighty-eight patients with painful chronic pancreatitis were included and followed for 18 months. Patients randomized to early surgical drainage procedures had less chronic pain (P=0.02). Complete or partial pain relief was experienced by 58 per cent after surgery versus 39 per cent in controls, P=0.01.

Pubmed Link

You may also be interested in

Scientific Surgery

Treatment for Infected pancreatic necrosis should be delayed, possibly avoiding an open surgical approach. A systematic review and network meta-analysis. Ann Surg 2021; 273: 251-257.

Authors: Ricci C, Pagano N, Ingaldi C, Frazzoni L, Migliori M, Alberici L et al.

Scientific Surgery

Urgent endoscopic retrograde cholangiopancreatography with sphincterotomy versus conservative treatment in predicted severe acute gallstone pancreatitis (APEC): a multicentre randomised controlled trial. Lancet 2020; 396: 167-176.

Authors: Schepers NJ, Hallensleben NDL, Besselink MG, Anten M-PG, Bollen TL, da Costa DW et al.

Scientific Surgery

Gallstone pancreatitis: admission versus normal cholecystectomy—a randomized trial (Gallstone PANC Trial). Ann Surg 2019; 270: 519-527

Authors: Mueck K, Wei S , Pedroza C , Bernardi K , Jackson ML , Liang MK et al.

Scientific Surgery

Acute pancreatitis: recent advances through randomised trials. Gut 2017; 66: 2024-2032.

Authors: Van Dijk SM, Hallensleben NDL, van Santvoort HC, Fockens P, van Goor H, Bruno MJ et al.

Scientific Surgery

Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet 2018; 391: 51–58.

Authors: Van Brunschot S, van Grinsven J, van Santvoort HC, Bakker OJ, Besselink MG, Boermeester MA et al.

Scientific Surgery

Can laparoscopic cholecystectomy prevent recurrent idiopathic acute pancreatitis? A prospective randomized multicenter trial. Ann Surg 2015; 262: 736–741.

Authors: Räty S, Pulkkinen J, Nordback I, Sand J, Victorzon M, Grönroos J et al. et al.

Scientific Surgery

Same-admission versus interval cholecystectomy for mild gallstone pancreatitis (PONCHO): a multicentre randomised controlled trial. Lancet 2015; 386: 1261–1268.

Authors: Da Costa DW, Bouwense SA, Schepers NJ, Besselink MG, van Santvoort HC, van Brunschot S et al for the Dutch Pancreatitis Study Group et al.

Scientific Surgery

Synbiotics in surgery for chronic pancreatitis: are they truly effective? A single-blind prospective randomized control trial. Ann Surg 2015; 262: 31-37.

Authors: Rammohan A, Sathyanesan J, Rajendran K, Pitchaimuthu A, Perumal S, Balaraman K et al. et al.

Scientific Surgery

Early versus on-demand nasoenteric tube feeding in acute pancreatitis. N Engl J Med 2014; 371: 1983-1993.

Authors: Bakkar OJ, van Brunschot S, van Santvoort HC, Besselink MG, Bollen TL, Boermeester MA et al. et al.

Scientific Surgery

A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med 2012; 366: 1414–1422.

Authors: Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosier P, Higgins PDR et al. et al.

Scientific Surgery

Endoscopic transgastric vs. surgical necrosectomy for infected necrotizing pancreatitis. A randomized trial. JAMA 2012; 307: 1053–1061.

Authors: Bakker OJ, van Santvoort HC, van Brunschot S, Geskus RB, Besselink MG, Bollen TL et al. et al.

Scientific Surgery

Prophylactic antibiotics reduce pancreatic necrosis in acute necrotizing pancreatitis: a meta-analysis of randomized trials. Digest Surg 2010; 27: 442–449.

Authors: Yao L, Huang X, Shi R, Zhang G.