This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Adjuvant chemotherapy with fluorouracil plus folinic acid versus gemcitabine following pancreatic cancer resection: a randomized controlled trial. JAMA 2010; 304: 1073-1081.
Published: 2nd February 2011
Authors: Neoptolemos JP, Stocken DD, Bassi C, Ghaneh P, Cunningham D, Goldstein D et al. et al.
Conclusion
Over one thousand patients were included and followed for a minimum of 2 years (median 34.2 months). There was no difference in median survival between the two regimens: 23.0 months with fluorouracil, 23.6 months with gemcitabine. There were fewer serious side effects with gemcitabine (7.5 vs. 14 per cent, P<0.001).
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