This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A single preoperative dose of tranexamic acid reduces perioperative blood loss. A meta-analysis. Ann Surg 2021; 273: 75-81.

Published: 7th April 2021

Authors: Heyns M, Knight P, Steve AK, Yeung JK

Conclusion

This analysis included 57 RCTs involving 5697 procedures across five surgical specialties, the largest being orthopaedics. A single dose of tranexamic acid reduced mean estimated blood loss by 153ml (95 per cent confidence interval 119 to 188ml) and the need for blood transfusion by two thirds (odds ratio 0.28, 0.22 to 0.36). Thromboembolic events were not increased.

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