The international surgical journal with global reach

This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS

A randomized Phase II trial of adjuvant hepatic arterial infusion and systemic therapy with or without panitumumab after hepatic resection of KRAS wild-type colorectal cancer. Ann Surg 2021; 274: 248-254.

Published: 24th November 2021

Authors: Kemeny NE, Chou JF, Capanu M, Chatila WK, Shi H, Sanchez-Vega F et al.

Conclusion

In this study that included 75 patients, the addition of panitumumab improved three year recurrence-free survival from 42 to 57 per cent.

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Preoperative hepatic and regional arterial chemotherapy in patients who underwent curative colorectal cancer resection. A prospective, multi-center, randomized controlled trial. Ann Surg 2021; 273: 1066-1075.

Authors: Zhu D, Xia J, Gu Y, Lin J, Ding K, Zhou B et al.

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Effect of celecoxib vs placebo added to standard adjuvant therapy on disease-free survival among patients with stage III colon cancer. The CALGB/SWOG 80702 (Alliance) randomized clinical trial. JAMA 2021; 325: 1277-1286.

Authors: Meyerhardt JA, Shi Q, Fuchs CS, Meyer J, Niedzwiecki D, Zemla T et al.

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Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE 7): a multicentre, randomised, open label, phase 3 trial. Lancet Oncol 2021; 22: 256-266.

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Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials. Lancet Oncol 2020; 21: 1620-1629.

Authors: Andre T, Meyerhardt J, Iveson T, Sobrero A, Yoshino T, Souglakos I et al.

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Perioperative FOLFOX 4 versus FOLFOX 4 plus Cetuximab versus immediate surgery for high-risk stage II and III colon cancers. A phase II multicenter randomized controlled trial (PRODIGE 22). Ann Surg 2020; 271: 637-645

Authors: Karoui M, Rullier A, Piessen G, Legoux JL, Barbier E, De Chaisemartin C et al.

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Quality of life after curative resection for rectal cancer in patients treated with adjuvant chemotherapy compared with observation: results of the randomized phase III SCRIPT Trial. Dis Colon Rectum 2019; 62: 711-720

Authors: van der Valk MJ, Hilling DE, Meershoek-Klein Kranenbarg E, Peeters K, Kapiteijn E, Tsonaka R et al.

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Does a longer waiting period after neoadjuvant radio-chemotherapy improve the oncological prognosis of rectal cancer? Three years’ follow-up results of the Greccar-6 randomized multicenter trial. Ann Surg 2019; 270: 747-754

Authors: Lefèvre J, Mineur L, Cachanado M, Denost Q, Rouanet P, de Chaisemartin C et al.

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Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicenter, open-label, randomized trial. Lancet Gastroenterol Hepatol 2019; 4: 761-770

Authors: Klaver CEL, Wisselink DD , Punt CJA , Snaebjornsson P , Crezee J, Aalbers AG et al.

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Quadratus lumborum block versus perioperative intravenous lidocaine for postoperative pain control in patients undergoing laparoscopic colorectal surgery: a prospective, randomized, double-blind controlled clinical trial. Ann Surg 2018; 268: 769-775.

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Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med 2018; 378: 1177-1188.

Authors: Grothey A, Sobrero AF, Shields AF, Yoshino T, Paul J, Taieb J et al.

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A randomized control trial of preoperative oral antibiotics as adjunct therapy to systemic antibiotics for preventing surgical site infection in clean contaminated, contaminated, and dirty type of colorectal surgeries. Dis Colon Rectum 2017; 60: 1291-1298.

Authors: Anjum N, Ren J, Wang G, Li G, Wu X, Dong H et al.

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Effect of coffee on the length of postoperative ileus after elective laparoscopic left-sided colectomy: a randomized, prospective single-center study. Dis Colon Rectum 2015; 58: 1064-1069.

Authors: Dulskas A, Klimovskij M, Vitkauskiene M, Samalavicius N