This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Treatment of peritoneal carcinomatosis from adenocarcinoid of appendiceal origin. BJS 2004; 91: 1168-1173.
Published: 22nd June 2004
Authors: H. Mahteme, P. H. Sugarbaker
Background
Mucinous peritoneal carcinomatosis arising from appendiceal adenocarcinoid is uncommon and treatment options have been poorly defined. This study examined the effect of combined cytoreductive surgery and intraperitoneal chemotherapy on survival in these patients.
Method
Of 810 patients with peritoneal malignancy of appendiceal origin treated by cytoreductive surgery and intraperitoneal chemotherapy, 22 patients (mean age 45 years; 17 women) had adenocarcinoid.
Results
The overall median survival was 18·5 (range 3·2–95·1) months, with 2‐ and 5‐year survival rates of 39 and 25 per cent respectively. Survival after combined surgery and chemotherapy depended on the Peritoneal Cancer Index (P = 0·008) and the extent of cytoreduction (P = 0·007).
Conclusion
Peritoneal carcinomatosis from adenocarcinoid of appendiceal origin is as invasive as peritoneal surface malignancy from colorectal adenocarcinoma. Patients in whom complete or near‐complete surgical removal is possible should be considered for cytoreduction in combination with intraperitoneal chemotherapy. Copyright © 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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