This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Synaptotagmin XIII expression and peritoneal metastasis in gastric cancer. BJS 2018; 105: 1349-1358.
Published: 9th May 2018
Authors: M. Kanda, D. Shimizu, H. Tanaka, C. Tanaka, D. Kobayashi, M. Hayashi et al.
Background
Peritoneal metastasis is a frequent cause of death in patients with gastric cancer. The aim of this study was to identify molecules responsible for mediating peritoneal metastasis of gastric cancer.
Method
Transcriptome and bioinformatics analyses were conducted to identify molecules associated with peritoneal metastasis. The therapeutic effects of intraperitoneally administered small interfering (si) RNA were evaluated using mouse xenograft models. Expression of mRNA and protein was determined in gastric tissues from patients with gastric cancer.
Results
Synaptotagmin XIII (
Conclusion
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