This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Randomized clinical trial of 24 versus 72 h antimicrobial prophylaxis in patients undergoing open total gastrectomy for gastric cancer. BJS 2017; 104: e158-e164.
Published: 25th January 2017
Authors: A. Takagane, Y. Mohri, T. Konishi, R. Fukushima, T. Noie, S. Sueyoshi et al.
Background
Open total gastrectomy carries a high risk of surgical‐site infection (
Method
An open‐label, randomized, non‐inferiority study was conducted at 57 institutions in Japan. Eligible patients were those who underwent open total gastrectomy for gastric cancer. Patients were assigned randomly to continued use of β‐lactamase inhibitor for either 24 or 72 h after surgery. The primary endpoint was the incidence of
Results
A total of 464 patients (24 h prophylaxis, 228; 72 h prophylaxis, 236) were analysed.
Conclusion
Antimicrobial prophylaxis for 24 h after total gastrectomy is not inferior to 72 h prophylaxis for prevention of
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