This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Prospective audit following the introduction of short‐course preoperative radiotherapy for rectal cancer. BJS 2000; 87: 97-99.
Published: 10th December 2002
Authors: S. Lele, D. Radstone, J. Eremin, R. Kendal, K. B. Hosie
Background
The value of introducing a short course of preoperative radiotherapy before operation for rectal cancer is still subject to debate.
Method
One hundred consecutive patients, of mean age 68 (range 29–87) years undergoing preoperative radiotherapy for rectal cancer between January 1997 and December 1998 at two radiotherapy centres were audited prospectively.
Results
The time from referral to radiotherapy was 33 (11–74) days and from radiotherapy to operation 5 (1–42) days. There was a higher than expected anastomotic leak rate (15 per cent) and perineal wound infection rate (18 per cent). Patients waiting more than 7 days were more likely to suffer perineal wound breakdown: 15 per cent (n = 39) versus 30 per cent (n = 10).
Conclusion
The high anastomotic leak and perineal wound infection rates suggest that the introduction of preoperative radiotherapy combined with total mesorectal excision should be audited carefully or performed as part of the CRO7 trial. © 2000 British Journal of Surgery Society Ltd
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