This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Prognostic value of the cancer oncogene Kelch‐like 6 in gastric cancer. BJS 2017; 104: 1847-1856.
Published: 17th October 2017
Authors: J. Deng, J. Guo, G. Ma, H. Zhang, D. Sun, Y. Hou et al.
Background
Kelch‐like 6 (
Method
Associations between clinicopathological and survival data and KLHL6 expression in GC tissues were analysed. The effects of downregulation of KLHL6 in GC cells was investigated using proliferation, invasion, apoptosis and lymphangiogenesis assays, and analysis of tumour growth in an
Results
KLHL6 was upregulated in 43 per cent of GC tissues compared with 5 per cent of paired non‐tumour tissues from 84 patients. KLHL6 protein expression in GC tissues was much higher than that in atrophic gastritis, intestinal metaplasia and dysplasia tissues from benign gastric disease samples. KLHL6 expression was positively related to the intestinal Laurén classification in GC tissues. Downregulated expression of KLHL6 in MGC‐803 GC cells reduced colony formation, proliferation, viability, migration and invasion, enhanced apoptosis and inhibited the cell cycle in the G1 phase. Downregulated expression of KLHL6 also suppressed tumour growth in mice. Furthermore, downregulated expression of KLHL6 mRNA reduced the expression of nuclear‐associated antigen Ki‐67, vascular endothelial growth factor C, hepatocyte growth factor and matrix metalloproteinase 2
Conclusion
Abnormal expression of the
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