This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Prevention of postsurgical adhesions using an ultrapure alginate‐based gel. BJS 2013; 100: 904-910.
Published: 17th April 2013
Authors: A. A. Chaturvedi, R. M. L. M. Lomme, T. Hendriks, H. van Goor
Background
Postoperative adhesion formation is a common consequence of abdominal surgery, and constitutes a major source of morbidity and mortality. This study evaluated an ultrapure alginate‐based antiadhesive barrier gel.
Method
Experiments were performed in a rat model with caecal abrasion and peritoneal side wall excision. The primary endpoint was the incidence of adhesions at 14 days after surgery. In experiment 1 (24 rats), animals treated with alginate gel were compared with controls that had no antiadhesive barrier. In experiment 2 (42 rats), alginate gel was compared with sodium hyaluronate carboxymethyl cellulose (
Results
In experiment 1, ultrapure alginate gel reduced the incidence of adhesions from eight of 12 in control animals to one in 12 (
Conclusion
Ultrapure alginate gel decreased the incidence of postoperative adhesion formation in this rat model.
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