This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Perioperative use of a neutrophil elastase inhibitor in video‐assisted thoracoscopic oesophagectomy for cancer. BJS 2011; 98: 975-982.
Published: 9th May 2011
Authors: H. Makino, C. Kunisaki, T. Kosaka, H. Akiyama, S. Morita, I. Endo et al.
Background
This study was undertaken to assess the value of administering perioperative sivelestat sodium hydrate (SSH), a selective neutrophil elastase inhibitor, after video‐assisted thoracoscopic oesophagectomy for cancer.
Results
The mean P/F ratio of patients who received SSH was significantly higher than that of the control group on postoperative days 1–5 and 7. Duration of mechanical ventilation and SIRS, and length of ICU stay were significantly shorter in the treatment group. Serum CRP concentration on postoperative day 9 was significantly lower (P = 0·048), platelet counts on days 2, 3 and 5 were higher (P = 0·012, P = 0·049 and P = 0·006 respectively), and the incidence of postoperative acute lung injury was significantly lower following SSH treatment (P = 0·023).
Conclusion
Perioperative sivelestat may maintain postoperative pulmonary function following video‐assisted oesophagectomy. Registration number: NCT01170845 (