This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Ovarian ablation in the adjuvant treatment of premenopausal and perimenopausal breast cancer. BJS 2003; 90: 517-526.
Published: 7th April 2003
Authors: R. Sainsbury
Background
Ovarian ablation has been employed in the treatment of breast cancer for many decades and, more recently, its value as an adjuvant treatment for premenopausal women with early‐stage disease has been clearly demonstrated. This review examines the different methods of achieving ovarian ablation and assesses the relevance of ovarian suppression as a treatment aim.
Method
Medline searches were used to identify recent key articles relating to the adenoma–carcinoma sequence. Further relevant articles were obtained by manual scanning of the reference lists of selected papers.