This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Oncological impact of anastomotic leakage after laparoscopic mesorectal excision. BJS 2017; 104: 288-295.
Published: 20th October 2016
Authors: E. Hain, L. Maggiori, G. Manceau, C. Mongin, J. Prost à la Denise, Y. Panis et al.
Background
The effect of anastomotic leakage on oncological outcomes after total mesorectal excision (
Method
All patients who underwent restorative laparoscopic
Results
Of a total of 428 patients, anastomotic leakage was observed in 120 (28·0 per cent) (50 asymptomatic, 70 symptomatic). After a mean follow‐up of 40 months, local recurrence was observed in 36 patients (8·4 per cent). Multivariable Cox regression identified three independent risk factors for reduced local recurrence‐free survival (
Conclusion
Symptomatic anastomotic leakage is a risk factor for disease recurrence in patients with rectal adenocarcinoma.
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