This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
MiR‐128 regulation of glucose metabolism and cell proliferation in triple‐negative breast cancer. BJS 2018; 105: 75-85.
Published: 8th November 2017
Authors: M. Xiao, C. Lou, H. Xiao, Y. Yang, X. Cai, C. Li et al.
Background
Triple‐negative breast cancer (TNBC) is prone to metastasis and has a poor prognosis, with lower survival rates than other breast cancer subtypes. MicroRNAs have recently emerged as powerful regulators of cancer processes and become a promising target in cancer therapy.
Method
Expression of miR‐128 was examined in invasive ductal breast cancer, and its relationship with clinicopathological features analysed. A series of
Results
A cohort of 110 women with TNBC and 117 with non‐TNBC were included in the study. In multivariable Cox regression analysis, overall and disease‐free survival were significantly associated with lymph node metastasis, histological grade and molecular subtype. Subgroup analysis showed that low expression of miR‐128 correlated with shorter overall and disease‐free survival in TNBC (
Conclusion
MiR‐128 might be a prognostic marker and possible molecular target for therapy in patients with TNBC.
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