This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Meta‐analysis of the association between alcohol consumption and abdominal aortic aneurysm. BJS 2017; 104: 1756-1764.
Published: 7th September 2017
Authors: S. M. Spencer, A. J. Trower, X. Jia, D. J. A. Scott, D. C. Greenwood
Background
Alcohol is a possible risk factor for abdominal aortic aneurysm (AAA), but evidence from individual studies is weak and inconsistent. Existing narrative reviews suggest the possibility of non‐linear associations. The aim here was to quantify any association using a systematic literature review, followed by dose–response meta‐analysis of prospective studies.
Method
MEDLINE, Embase and Web of Science were searched systematically to January 2017 for relevant prospective studies of alcohol consumption and AAA risk. Summary estimates of highest
Results
Eleven relevant cohorts were identified describing results from 3580 individuals with among 473 092 participants. Data were extracted from ten cohorts for meta‐analyses of high
Conclusion
Although the linear dose–response analysis revealed little evidence of an association between alcohol consumption and AAA risk, a tick‐shaped trend in the association was observed. This non‐linear dose–response analysis revealed reduced risks for alcohol consumption below 2 units/day, masking increased risks for 2 or more units/day.
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