This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
In vitro effects of proteases in human pancreatic juice on stability of liquid and carrier‐bound fibrin sealants. BJS 2013; 100: 1498-1504.
Published: 4th September 2013
Authors: J. Adelmeijer, R. J. Porte, T. Lisman
Background
Fibrin sealants are used in pancreatic surgery to prevent leakage of pancreatic fluid and reduce associated complications. The efficacy of this approach is unclear.
Method
Fibrin clots were generated
Results
Clots generated from liquid fibrin sealants degraded rapidly in pancreatic fluid, but not in normal saline. D‐dimer release from fibrin clots by pancreatic fluid was approximately 1700 µg/ml after 24 h and less than 20 µg/ml by saline. Pancreatic fluid, but not normal saline, degraded both the fibrin and collagen component of Tachosil®. After 6 h, mean(s.e.m.) D‐dimer levels in pancreatic fluid exposed to Tachosil
Conclusion
Proteases in pancreatic juice effectively degrade both liquid and carrier‐bound fibrin sealants
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