This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Effect of orthotopic small bowel transplantation on mineral metabolism in an experimental model. BJS 2005; 92: 764-771.
Published: 26th April 2005
Authors: S. Kastl, V. Müller, U. Kotschenreuther, M. Radespiel‐Troeger, W. Hohenberger, R. G. Erben et al.
Background
Numerous experimental models have been described for investigation of short bowel syndrome. The aim of this study was to examine the effect of orthotopic small bowel transplantation (OSBT) on universal metabolism in an inbred rat model, with particular emphasis on mineral metabolism.
Method
Jejunoileal resection and syngeneic OSBT was performed in 12‐week‐old male Lewis rats. Metabolic studies were performed over the following 16 weeks. Bones were analysed by physicochemical methods, dual X‐ray absorptiometry, biomechanical procedures and histomorphometry. Biochemical markers of bone turnover were also measured.
Results
Jejunoileal resection induced severe short bowel syndrome with profoundly reduced food efficiency, bone size, fracturing energy and bone mineral content, but no cancellous bone osteopenia. After OSBT rats showed normal growth; bones were of normal size, and bone mineral content and fracturing energy were similar to those in sham‐operated controls. However, tibial, but not vertebral, cancellous bone osteopenia was found after transplantation.
Conclusion
OSBT with portal venous drainage achieves almost optimal mineral and bone metabolism. In the absence of immunosuppressive therapy, OSBT does not appear to have major untoward side‐effects on bone in rats. Copyright © 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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