This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Effect of local injection of mesenchymal stem cells on healing of sutured gastric perforation in an experimental model. BJS 2015; 102.
Published: 27th January 2015
Authors: L. Liu, P. W. Y. Chiu, P. K. Lam, C. C. Y. Poon, C. C. H. Lam, E. K. W. Ng et al.
Background
Mesenchymal stem cells are proposed to facilitate repair of organ injuries. The aim of this study was to investigate whether local injection of mesenchymal stem cells could accelerate healing of sutured gastric perforations.
Method
Sutured gastric perforations in rats were treated either with local injection of mesenchymal stem cells (injected
Results
Local injection of mesenchymal stem cells significantly promoted the healing of gastric perforations, with the highest pneumatic bursting pressure (mean(s.e.m.) 112·3(30·2)
Conclusion
Local injection of mesenchymal stem cells was more effective than topical application, and enhanced the healing of sutured gastric perforations by an anti‐inflammatory process, enhanced cellular proliferation and earlier onset of granulation. Abnormal healing of gastric perforation may cause morbidity and increase the risk of death. Adipose tissue‐derived mesenchymal stem cells have been found to promote the healing of organ injuries through cellular differentiation and secretion of cytokines that stimulate cellular proliferation and angiogenesis, and suppress inflammation.
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