This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra‐appendicular origin. BJS 2018; 105: 668-676.
Published: 7th February 2018
Authors: J.‐B. Delhorme, F. Severac, G. Averous, O. Glehen, G. Passot, N. Bakrin et al.
Background
The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra‐appendicular PMP (EA‐PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Method
All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database. Patients with EA‐PMP had pathologically confirmed non‐neoplastic appendices and were matched in a 1 : 4 ratio with patients treated for appendicular PMP (A‐PMP), based on a propensity score.
Results
Some 726 patients were identified, of which 61 (EA‐PMP group) were matched with 244 patients (A‐PMP group). The origins of primary tumours in the EA‐PMP group included the ovary (45 patients), colon (4), urachus (4), small bowel (1), pancreas (1) and unknown (6). The median peritoneal carcinomatosis index was comparable in EA‐PMP and A‐PMP groups (15·5
Conclusion
Overall and disease‐free survival following treatment with CCRS and HIPEC is similar in patients with pseudomyxoma peritonei of appendicular or extra‐appendicular origin.
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