This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Cytokine gene polymorphisms and the inflammatory response to abdominal aortic aneurysm repair. BJS 2003; 90: 1085-1092.
Published: 31st July 2003
Authors: M. J. Bown, T. Horsburgh, M. L. Nicholson, P. R. F. Bell, R. D. Sayers
Background
Cytokines are key mediators of the inflammatory response to surgery and polymorphic sites in their genes have been shown to affect cytokine production in vitro. The aim of this study was to determine whether cytokine gene polymorphisms affect cytokine production in vivo in patients undergoing abdominal aortic aneurysm (AAA) repair.
Method
One hundred patients admitted for elective AAA repair had plasma levels of interleukin (IL) 1β, IL‐6, IL‐10 and tumour necrosis factor (TNF) α measured at induction of anaesthesia and 24 h after operation. Genotypes for each patient were determined using induced heteroduplex genotyping for the following loci: IL‐1β + 3953, IL‐6 − 174, IL‐10 − 1082/−592 and TNF‐α − 308.
Results
Patients with an IL‐10 − 1082 A allele had a significantly higher IL‐10 response to surgery than those without an A allele (P = 0·030) and there was also a significant difference in IL‐10 response between patients with IL‐10 − 1082 AA genotypes and those with GG genotypes (P = 0·030).
Conclusion
Elective AAA repair results in a measurable cytokine response. In this study the magnitude of this response was not affected by the individual patient's cytokine gene polymorphisms. Copyright © 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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