This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease. BJS 2003; 90: 23-28.
Published: 8th January 2003
Authors: T. Itamoto, K. Katayama, H. Nakahara, H. Tashiro, T. Asahara
Background
Preoperative autologous blood donation has been suggested for patients with liver disease who are to undergo liver resection. The aim of this retrospective study was to clarify the risk factors for increased blood loss and the need for blood transfusion during hepatectomy for hepatocellular carcinoma (HCC).
Method
From January 1996 to December 2000, 206 consecutive patients, 98·5 per cent of whom had underlying liver disease, underwent elective hepatectomy for HCC.
Results
Major hepatectomy was performed in 34 patients (16·5 per cent) and minor hepatectomy in 172 patients (83·5 per cent). The mean blood loss was 410 (median 260) ml. Eleven (5·3 per cent) of the 206 patients received blood transfusion during or after the operation. Operation time (P = 0·004) and central venous pressure (CVP) (P = 0·041) were independently correlated with blood loss of more than 1000 ml. Only preoperative haemoglobin level (P = 0·001) was independently correlated with the need for blood transfusion.
Conclusion
In patients with underlying liver disease, maintaining CVP at a level below 5 cmH2O during parenchymal transection to reduce blood loss is more important than reserving autologous blood before the operation. Copyright © 2003 British Journal of Surgery Society Ltd. Published by John Wiley & Sons Ltd
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