This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Association of visceral adiposity with oesophageal and junctional adenocarcinomas. BJS 2010; 97: 1028-1034.
Published: 14th May 2010
Authors: P. Beddy, J. Howard, C. McMahon, M. Knox, C. de Blacam, N. Ravi et al.
Background
Obesity is associated with an increased incidence of oesophageal and oesophagogastric junction adenocarcinoma, in particular Siewert types I and II. This study compared abdominal fat composition in patients with oesophageal/junctional adenocarcinoma with that in patients with oesophageal squamous cell carcinoma and gastric adenocarcinoma, and in controls.
Results
Patients with oesophageal/junctional adenocarcinoma had significantly higher TFA and VFA values compared with controls (both P < 0·001), patients with gastric adenocarcinoma (P = 0·013 and P = 0·006 respectively) and patients with oesophageal squamous cell carcinoma (both P < 0·001). For junctional tumours, the highest TFA and VFA values were seen in patients with Siewert type I tumours (respectively P = 0·041 and P = 0·033 versus type III; P = 0·332 and P = 0·152 versus type II).
Conclusion
Patients with oesophageal/junctional adenocarcinoma, in particular oesophageal and Siewert type I junctional tumours, have greater CT‐defined visceral adiposity than patients with gastric adenocarcinoma or oesophageal squamous cell carcinoma, or controls. Copyright © 2010 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
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