This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn’s disease: a phase 3 randomised, double-blind controlled trial. Lancet 2016; 388: 1281–1290.
Published: 16th January 2017
Authors: Panes J, Garcia-Olmo D, Van Assche G, Colombel JF, Reinisch W, Baumgart DC et al.
Conclusion
In this multicentre study, 212 patients with chronic refractory fistulas were randomized. The active treatment was associated with a better chance of remission at six months: 50 per cent versus 34 per cent with placebo, P=0.024.
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