This is the Scientific Surgery Archive, which contains all randomized clinical trials in surgery that have been identified by searching the top 50 English language medical journal issues since January 1998. Compiled by Jonothan J. Earnshaw, former Editor-in-Chief, BJS
Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. J Clin Oncol 2011; 29: 4387–4393.
Published: 4th April 2012
Authors: Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T et al. et al.
Conclusion
The addition of a year of chemotherapy (oral fluoropyrimidine derivative S-1) improved both 5-year relapse-free survival (65 versus 53 per cent) and overall survival 72 versus 61 per cent: hazard ratio 0.67, 95 per cent confidence interval 0.54 to 0.83.
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